Fernando Gabriel Manzur Jattin
Universidad de Cartagena, Colombia.
Title: Canakinumab: a promising monoclonal antibody in the treatment of cardiovascular diseases
Biography
Biography: Fernando Gabriel Manzur Jattin
Abstract
Canakinumab is a totally human monoclonal antibody anti-IL-1β developed by Novartis, whose mode of action is based on the neutralization of IL-1β signaling, which leads to suppression of inflammation in patients with autoimmune disorders. The IL-1β acts as a mediator of the peripheral immune response during infection and inflammation. By the antigen-antibody binding, canakinumab inhibits the action of IL1-β avoiding its pro-inflammatory effects. Currently, it is being evaluated as a new possible agent directed against IL-1β, with the goal of reducing the rate of cardiovascular events and new onset diabetes.